Deformation of canonical morphisms and the moduli of surfaces of general type

In this article we study the deformation of finite maps and show how to use this deformation theory to construct varieties with given invariants in a projective space. Among other things, we prove a criterion that determines when a finite map can be deformed to a one--to--one map. We use this criterion to construct new simple canonical surfaces with different $c_1^2$ and $\chi$. Our general results enable us to describe some new components of the moduli of surfaces of general type. We also find infinitely many moduli spaces $\mathcal M_{(x',0,y)}$ having one component whose general point corresponds to a canonically embedded surface and another component whose general point corresponds to a surface whose canonical map is a degree 2 morphism.Comment: 32 pages. Final version with some simplifications and clarifications in the exposition. To appear in Invent. Math. (the final publication is available at springerlink.com

Assessment of the corneal collagen organization after chemical burn using second harmonic generation microscopy

The organization of the corneal stoma is modified due to different factors, including pathology, surgery or external damage. Here the changes in the organization of the corneal collagen fibers during natural healing after chemical burn are investigated using second harmonic generation (SHG) imaging. Moreover, the structure tensor (ST) was used as an objective tool for morphological analyses at different time points after burn (up to 6 months). Unlike control corneas that showed a regular distribution, the collagen pattern at 1 month of burn presented a non-organized arrangement. SHG signal levels noticeably decreased and individual fibers were hardly visible. Over time, the healing process led to a progressive re-organization of the fibers that could be quantified through the ST. At 6 months, the stroma distribution reached values similar to those of control eyes and a dominant direction of the fibers re-appeared. The present results show that SHG microscopy imaging combined with the ST method is able to objectively monitor the temporal regeneration of the corneal organization after chemical burn. Future implementations of this approach into clinically adapted devices would help to diagnose and quantify corneal changes, not only due to chemical damages, but also as a result of disease or surgical procedures

A population density grid for Spain

This is an author's accepted manuscript of an article published in "International Journal of Geographical Information Science"; Volume 27, Issue 12, 2013; copyright Taylor & Francis; available online at: http://www.tandfonline.com/doi/abs/10.1080/13658816.2013.799283This article describes a high-resolution land cover data set for Spain and its application to dasymetric population mapping (at census tract level). Eventually, this vector layer is transformed into a grid format. The work parallels the effort of the Joint Research Centre (JRC) of the European Commission, in collaboration with Eurostat and the European Environment Agency (EEA), in building a population density grid for the whole of Europe, combining CORINE Land Cover with population data per commune. We solve many of the problems due to the low resolution of CORINE Land Cover, which are especially visible with Spanish data. An accuracy assessment is carried out from a simple aggregation of georeferenced point population data for the region of Madrid. The bottom-up grid constructed in this way is compared to our top-down grid. We show a great improvement over what has been reported from commune data and CORINE Land Cover, but the improvements seem to come entirely from the higher resolution data sets and not from the statistical modeling in the downscaling exercise. This highlights the importance of providing the research community with more detailed land cover data sets, as well as more detailed population data. The dasymetric grid is available free of charge from the authors upon request.The authors acknowledge financial support from the BBVA Foundation-Ivie research programme and the first author also acknowledges support from the Spanish Ministry of Science and Technology, ECO2011-23248 project. Results mentioned, but not shown, are available from the authors upon request. The grid numbers are also available from the authors.Goerlich Sanchis, FJ.; Cantarino Martí, I. (2013). A population density grid for Spain. International Journal of Geographical Information Science. 27(12):1-17. https://doi.org/10.1080/13658816.2013.799283S117271

Estimating the Relationship between Reading in Primary Education, Educational Attainment and Social Welfare. The Case of Extremadura (Spain)

The purpose of this paper is to analyse the relationship between the Social Welfare Index and the reading habits of primary school students in Extremadura (Spain). A study has been performed which consists of two parts. First, we conducted 4,288 surveys on reading habits in 87 municipalities. Second, we calculated the social welfare index. The statistical analysis refl ects two conclusions: firstly, educational and socio-economic policies have resulted in equal opportunities that allow for similar social possibilities throughout the territory; secondly, Educational Attainment of parents is the most decisive factor in obtaining the best results in terms of students' reading habits

Palaeoenvironment of Eocene prodelta in Spitsbergen recorded by the trace fossil Phycosiphon incertum

Ichnological, sedimentological and geochemical analyses were conducted on the Eocene Frysjaodden Formation in order to interpret palaeoenvironment prodelta sediments in the Central Basin of Spitsbergen. Phycosiphon incertum is the exclusive ichnotaxon showing differences in size, distribution, abundance and density, and relation to laminated/bioturbated intervals. Large P. incertum mainly occur dispersed, isolated and randomly distributed throughout the weakly laminated/non-laminated intervals. Small P. incertum occur occasionally in patches of several burrows within laminated intervals or as densely packed burrows in thin horizons in laminated intervals or constituting fully bioturbated intervals that are several centimetres thick. Ichnological changes are mainly controlled by oxygenation, although the availability of benthic food cannot be discarded. Changes in oxygenation and rate of sedimentation can be correlated with the registered variations in the Bouma sequence of the distal turbiditic beds within prodeltal shelf sediments.Funding for this research was provided by Project CGL2012-33281 (Secretaría de Estado de Investigación, Desarrollo e Innovación, Spain), Project RYC-2009-04316 (Ramón y Cajal Programme) and Projects RNM-3715 and RNM-7408 and Research Group RNM-178 (Junta de Andalucía). The authors benefited from a bilateral agreement between the universities of Granada and Oslo, supported by the University of Granada

Adenoma de las glándulas de Brunner

El adenoma de glándulas de Brunner representa el 10% de los tumores benignos del duodeno. Su localización más frecuente es en la primera porción del duodeno y es extremadamente raro por debajo de la ampolla de Vater. Presentamos dos casos, uno de ellos asociado a adenocarcinoma de la ampolla de Vater. Esta asociación no está descrita en la literatura. No existe ningún caso en que se demuestre una transformación de adenoma a adenocarcinoma. Para estas lesiones nodulares solitarias es más correcto el término de adenoma que el de hiperplasia, debiéndose reservar este último para las proliferaciones más difusas

Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

Altres ajuts: We would like to thank the "Fundación Ramón Areces," a Research Contract with the "Fundación Síndrome de Wolf-Hirschhorn o 4p-", and institutional grants from the "Fundación Ramón Areces" and "Banco de Santander" to the CBMSO. Research in the ISG group is partially supported by by Junta de Castilla y León (UIC-017, CSI001U16, and CSI234P18), and by the German Jose Carreras Foundation (DJCLS R13/26; DJCLS 07R/2019). AC-G and M.I.-H. are supported by FSE-Conserjería de Educación de la Junta de Castilla y León 2019 and 2020 (ESF- European Social Fund) fellowship, respectively. J.R.-G. is supported by a scholarship from University of Salamanca co-financed by Banco Santander and ESF.PAX5 is one of the most frequently mutated genes in B-cell acute lymphoblastic leukemia (B-ALL), and children with inherited preleukemic PAX5 mutations are at a higher risk of developing the disease. Abnormal profiles of inflammatory markers have been detected in neonatal blood spot samples of children who later developed B-ALL. However, how inflammatory signals contribute to B-ALL development is unclear. Here, we demonstrate that Pax5 heterozygosis, in the presence of infections, results in the enhanced production of the inflammatory cytokine interleukin-6 (IL-6), which appears to act in an autocrine fashion to promote leukemia growth. Furthermore, in vivo genetic downregulation of IL-6 in these Pax5 heterozygous mice retards B-cell leukemogenesis, and in vivo pharmacologic inhibition of IL-6 with a neutralizing antibody in Pax5 mutant mice with B-ALL clears leukemic cells. Additionally, this novel IL-6 signaling paradigm identified in mice was also substantiated in humans. Altogether, our studies establish aberrant IL6 expression caused by Pax5 loss as a hallmark of Pax5-dependent B-ALL and the IL6 as a therapeutic vulnerability for B-ALL characterized by PAX5 loss

Efficacy and safety of preoperative preparation with Lugol''s iodine solution in euthyroid patients with Graves’ disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial

Background: Currently, both the American Thyroid Association and the European Thyroid Association recommend preoperative preparation with Lugol''s Solution (LS) for patients undergoing thyroidectomy for Graves’ Disease (GD), but their recommendations are based on low-quality evidence. The LIGRADIS trial aims to provide evidence either to support or refute the systematic use of LS in euthyroid patients undergoing thyroidectomy for GD. Methods: A multicenter randomized controlled trial will be performed. Patients =18 years of age, diagnosed with GD, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy will be eligible for inclusion. Exclusion criteria will be prior thyroid or parathyroid surgery, hyperparathyroidism that requires associated parathyroidectomy, thyroid cancer that requires adding a lymph node dissection, iodine allergy, consumption of lithium or amiodarone, medically unfit patients (ASA-IV), breastfeeding women, preoperative vocal cord palsy and planned endoscopic, video-assisted or remote access surgery. Between January 2020 and January 2022, 270 patients will be randomized for either receiving or not preoperative preparation with LS. Researchers will be blinded to treatment assignment. The primary outcome will be the rate of postoperative complications: hypoparathyroidism, recurrent laryngeal nerve injury, hematoma, surgical site infection or death. Secondary outcomes will be intraoperative events (Thyroidectomy Difficulty Scale score, blood loss, recurrent laryngeal nerve neuromonitoring signal loss), operative time, postoperative length of stay, hospital readmissions, permanent complications and adverse events associated to LS. Conclusions: There is no conclusive evidence supporting the benefits of preoperative treatment with LS in this setting. This trial aims to provide new insights into future Clinical Practice Guidelines recommendations. Trial registration: ClinicalTrials.gov identifier: NCT03980132. © 202

RESUMEN PAPPS Infancia y Adolescencia 2020

En este documento de actualización presentamos cuatro temas trascendentes para la infancia y la adolescencia en nuestra actividad de atención primaria: el apoyo a la lactancia materna, la promoción de la actividad física, la prevención de lesiones infantiles por accidente de tráfico y el cribado de depresión mayor. Four important topics about children and adolescents in our Primary Care activity are presented in this update document: support for breastfeeding, promotion of physical activity, prevention of child injuries due to traffic accidents, and screening for major depressio